Structure-directed synthesis aims at the design and preparation of novel solid-state structures; using the structure-directing capability of some molecular additive, the so-called structure-directing agent. This general train of thought has led to the development of many weird and wonderful strategies. The book presents an in-depth review of the field and discusses the potential for further developments. Some of the topics are listed under 'Keywords'. The book references 343 original resources with their direct web links for in-depth reading.