Introduction to Biomedical Engineering, Fourth Edition, is a comprehensive survey text for biomedical engineering courses. It is the most widely adopted text across the BME course spectrum, valued by instructors and students alike for its authority, clarity, and encyclopedic coverage in a single volume. Biomedical engineers need to understand the wide range of topics that are covered in this text, including basic mathematical modeling, anatomy and physiology, electrical engineering, signal processing and instrumentation, biomechanics, biomaterials science, tissue engineering, and medical and engineering ethics The authors tackle these core topics at a level appropriate for senior undergraduate students and graduate students who are either majoring in BME or studying it as a combined course with a related engineering, biology or life science, or medical/pre-medical course. Revised and updated chapters throughout the book feature current research and developments in, for example, biomaterials, tissue engineering, biosensors, physiological modeling, and biosignal processing Contains more worked examples and end-of-chapter exercises than previous editions Provides a historical look at the major developments across biomedical domains and covers the fundamental principles underlying biomedical engineering analysis, modeling, and design Includes online bonus chapters on rehabilitation engineering and assistive technology, genomics and bioinformatics, and computational cell biology and complexity.