2069, Los Angeles. Decades after a bioterrorist attack decimated the population and left many of the survivors horribly mutated, the "norms" have forced mutants into dangerous areas known as red zones. And the tensions between the two groups are threatening to boil over.LAPD detective Cassandra Lee is known for her single- mindedness, and right now, she's got only one goal - track down the Bonebreaker, the man who murdered her father. But her quest for justice is derailed when LA comes under attack. The Aztec Empire, a Central American group determined to take back the U.S. territories that their Spanish ancestors once controlled, has led a mutant army into California.

Suddenly caught in the middle of a war, Lee must put all her energy into keeping her city safe while unearthing the political secrets of LA's shady mayor. And with the Bonebreaker hunting her down, losing focus even for a second could mean death.