Volume 1 Preface xxiii About the Author xxv About the Book xxvii Acknowledgments xxix List of Abbreviations xxxi 1 Rearrangement Reactions 1 Baeyer-Villiger Oxidation or Rearrangement 1 Mechanism 2 Application 2 Experimental Procedure (from patent US 5142093A) 3 Dakin Oxidation (Reaction) 3 Mechanism 4 Application 4 Experimental Procedure (from patent EP0591799B) 4 Bamberger Rearrangement 5 Mechanism 5 Experimental Procedure (from patent CN102001954B) 6 Beckmann Rearrangement 6 Mechanism 6 Application 7 Experimental Procedure (general) 7 Preparation of Caprolactam (from patent US 3437655A) 7 Benzilic Acid Rearrangement 8 Mechanism 9 Application 9 Experimental Procedure (from patent US20100249451B) 9 Baker-Venkataraman Rearrangement 9 Mechanism 10 Application 10 Experimental Procedure (from patent CN105985306B) 10 Claisen Rearrangement 11 Mechanism 11 Application 12 Experimental Procedure (from patent WO2016004632A1) 13 Eschenmoser-Claisen Rearrangement 13 Mechanism 13 Ireland-Claisen Rearrangement 14 Mechanism 14 Johnson-Claisen Rearrangement 15 Mechanism 15 Overman Rearrangement 15 Mechanism 16 Cope Rearrangement 16 Mechanism 17 Application 17 Experimental Procedure (from patent US 4421934A) 17 Curtius Rearrangement 17 Mechanism 18 Application 18 Experimental Procedure (from patent EP2787002A1) 19 Demjanov Rearrangement 19 Mechanism 20 Application 21 Experimental Procedure (from Reference [14], copyright 2008, American Chemical Society) 21 Tiffeneau-Demjanov Rearrangement 22 Mechanism 22 Application 23 Experimental Procedure (from Reference [10], copyright,The Royal Society of Chemistry) 23 Fries Rearrangement 23 Mechanism 24 Application 24 Experimental Procedure (from patent US9440940B2) 25 Favorskii Rearrangement 25 Mechanism 25 Application 26 Experimental Procedure (from patent EP3248959A2) 26 Fischer-Hepp Rearrangement 26 Mechanism 27 Experimental Procedure (general) 27 Hofmann Rearrangement (Hofmann degradation of amide) 28 Mechanism 28 Application 29 Experimental Procedure (from patent CN105153023B) 29 Hofmann-Martius Rearrangement 29 Mechanism 30 Experimental Procedure (from patent DD295338A5) 30 Lossen Rearrangement 31 Mechanism 31 Application 32 Experimental Procedure (from patent EP2615082B1) 32 Orton Rearrangement 32 Mechanism 33 Pinacol-Pinacolone Rearrangement 33 Mechanism 34 Application 34 Experimental Procedure (general) 34 Rupe Rearrangement/Meyer-Schuster Rearrangement 34 Rupe Rearrangement 35 Meyer-Schuster Rearrangement 35 Mechanism 35 Application 36 Experimental Procedure (from patent US4088681A) 36 Schmidt Rearrangement or Schmidt Reaction 36 Mechanism 37 Application 37 Experimental Procedure (from patent WO2009026444A1) 38 Wagner-Meerwein Rearrangement 38 Mechanism 38 Application 39 Wolff Rearrangement 39 Mechanism 39 Alternatively 40 Application 40 Experimental Procedure (from patent US9175041B2) 9175041B2 40 Arndt-Eistert Homologation or Synthesis 41 Mechanism 41 Application 42 Experimental Procedure (from patent US9399645B2) 42 Step 1 42 Step 2 42 Zinin Rearrangement or Benzidine and Semidine Rearrangements 42 Mechanism 43 Experimental Procedure (from patent US20090069602A1) 44 References 45 Baeyer-Villiger Oxidation or Rearrangement 45 Dakin Oxidation or Reaction 47 Bamberger Rearrangement 48 Beckmann Rearrangement 48 Benzilic Acid Rearrangement 50 Baker-Venkataraman Rearrangement 51 Claisen Rearrangement/Eschenmoser-Claisen Rearrangement/Ireland-Claisen Rearrangement/Johnson-Claisen Rearrangement/Overman Rearrangement 52 Cope Rearrangement 53 Curtius Rearrangement 54 Demjanov Rearrangement 56 Tiffeneau-Demjanov Rearrangement 56 Fries Rearrangement 56 Favorskii Rearrangement 58 Fischer-Hepp Rearrangement 58 Hofmann Rearrangement (Hofmann Degradation of Amide) 59 Hofmann-Martius Rearrangement 60 Lossen Rearrangement 60 Orton Rearrangement 61 Pinacol-Pinacolone Rearrangement 62 Rupe Rearrangement/Meyer-Schuster Rearrangement 62 Schmidt Rearrangement or Schmidt Reaction 63 Wagner-Meerwein Rearrangement 64 Wolff Rearrangement 65 Arndt-Eistert Homologation or Synthesis 66 Zinin Rearrangement or Benzidine and Semidine Rearrangements 67 2 Condensation Reaction 69 Aldol Condensation Reaction 69 Application 70 Experimental Procedure (general) 71 Enantioselective Aldol Reaction (from patent US 6919456B2) 71 Mukaiyama Aldol Reaction 72 Mechanism 72 Application 72 Experimental Procedure (from patent DE102013011081A1) 73 Evans Aldol Reaction 73 Mechanism 74 Application 74 Experimental Procedure (from patent WO2013151161A1) 74 Henry Reaction 75 Mechanism 75 Application 76 Experimental Procedure (from patent US 6919456B2) 76 Preparation of Chiral Catalyst 76 Nitro-Aldol Reaction 76 Benzoin Condensation 76 Mechanism 77 Application 77 Experimental Procedure (from patent DE3019500C2) 78 Claisen Condensation 78 Mechanism 78 Application 79 Experimental Procedure (from patent US9884836B2) 79 Darzens Glycidic Ester Condensation 80 Mechanism 80 Application 81 Experimental Procedure (from patent JP2009512630A) 81 Dieckmann Condensation 81 Mechanism 82 Application 82 Experimental Procedure (from patent US 7132564 B2) 82 Knoevenagel Condensation 83 Mechanism 83 Application 84 Lumefantrine 84 Experimental Procedure (from patent WO2010136360A2) 84 Pechmann Condensation (synthesis of coumarin) (also called von Pechmann condensation) 85 Mechanism 85 Application 86 Experimental Procedure (from patent US7202272B2) 86 Perkin Condensation or Reaction 86 Mechanism 87 Application 88 Experimental Procedure (from patent US4933001A) 88 Stobbe Condensation 88 Mechanism 89 Application 89 Experimental Procedure (from patent US20160137682A1) 90 References 90 Aldol Condensation Reaction 90 Mukaiyama Aldol Reaction 93 Evans Aldol Reaction 96 Henry Reaction 98 Benzoin Condensation 99 Claisen Condensation 101 Darzens Glycidic Ester Condensation 102 Dieckmann Condensation 103 Knoevenagel Condensation 105 Pechmann Condensation 106 Perkin Condensation or Reaction 107 Stobbe Condensation 108 3 Olefination, Metathesis, and Epoxidation Reactions 111 Olefination 111 Corey-Winter Olefin Synthesis 111 Mechanism 112 Application 112 Experimental Procedure (from patent US5807866A) 112 Horner-Wadsworth-Emmons Reaction 113 Mechanism 113 Application 113 Experimental Procedure (from patent JPWO2015046403A1) 114 Julia-Lythgoe Olefination 114 Mechanism 115 Modified Julia Olefination 115 Mechanism 115 Application 116 Experimental Procedure (from patent CN103313983A) 116 Julia-Kocienski Olefination 117 Application 117 Experimental Procedure (from patent WO2016125086A1) 118 Kauffmann Olefination 118 Mechanism 119 Application 119 Experimental Procedure (from patent WO2014183211A1) 119 Peterson Olefination 119 Mechanism 120 Application 121 Experimental Procedure (from patent WO2017149091A1) 121 Petasis Olefination 122 Mechanism 122 Application 123 Experimental Procedure (from patent US5087790A) 123 Tebbe Olefination 123 Mechanism 123 Application 124 Experimental Procedure (from patent US8809558B1) 124 Wittig Reaction or Olefination 124 Mechanism 125 Application 126 Experimental Procedure (from patent WO2006045010A2) 126 Metathesis 127 Olefin Metathesis 127 Ring-Closing Metathesis 127 Mechanism 128 Experimental Procedure (from patent US20022018351A1) 128 Cross Metathesis 128 Ring-Opening Metathesis 128 Ring-Opening Metathesis Polymerization (ROMP) 129 Asymmetric Epoxidation 129 Sharpless Asymmetric Epoxidation 129 Mechanism 129 Application 130 Experimental Procedure (from patent DE102014107132A1) (For more experimental procedures see Chapter 15) 130 Jacobsen-Katsuki Asymmetric Epoxidation 130 Mechanism 131 Application 131 Experimental Procedure (from patent US7501535B2) 132 Shi Asymmetric Epoxidation 132 Mechanism 133 Application 133 Experimental Procedure (from patent EP1770095A1) 133 Sharpless Asymmetric Dihydroxylation 134 Mechanism 135 Application 135 Experimental Procedure (from patent US7472570B1) 136 Sharpless Asymmetric Aminohydroxylation 136 Mechanism 137 Application 137 Experimental Procedure (from patent US8987504B2) 137