1.Nutrition and common diseases.- 1.1.Evolution of human nutrition.- 1.2.Principles of metabolism.
- 1.3.Dietary molecules.- 1.4.Nutrition and metabolic diseases.- 1.5.
Nutrition and cancer.- 1.6.Impact of physical activity.- 2.Human genomic variation.- 2.1.
Migration and evolutionary challenges of Homo sapiens.- 2.2.Diversity of human populations.- 2.3.Genetic variants of the human genome.- 2.
4.Haplotype blocks and GWAS.- 2.5.The 1000 Genomes Project.- 3.Sensing nutrition.- 3.
1.Nutrient-sensing mechanisms.- 3.2.Nuclear receptors as nutrient sensors.- 3.3.Functions and actions of PPARs.
- 3.4 Integration of lipid metabolism by LXRs and FXR.- 3.5.Coordination of the immune response by VDR.- 3.6.Circadian control of metabolic processes.
- 4.Interference of the human genome with nutrients.- 4.1.Human genetic adaptions.- 4.2.Genetic adaption to dietary changes.
- 4.3 Regulatory SNPs and quantitative traits.- 4.4.Nutrigenomic analysis.- 4.5 Personal omics profiles.- 5.
Nutritional epigenetics .- 5.1.Epigenetic mechanisms.- 5.2.Intermediary metabolism and epigenetic signaling.- 5.
3.Nutrition-triggered transgenerational epigenetic inheritance.- 5.4.Population epigenetics.- 6.Nutritional signaling and aging.- 6.
1 Aging and conserved nutrient-sensing pathways.- 6.2.Neuroendocrine regulation of aging.- 6.3.Principles of insulin signaling.- 6.
4.Central role of FOXO transcription factors.- 6.5.Caloric restriction from yeast to mammals.- 6.6.Cellular energy status sensing by sirtuins and AMPK.
- 7.Chronic inflammation and metabolic stress.- 7.1 Central role of monocytes and macrophages.- 7.2.Acute and chronic inflammation.- 7.
3.Reverse cholesterol transport and inflammation.- 7.4.Sensing metabolic stress via the ER.- 8.Obesity.- 8.
1 Definition of obesity.- 8.2 Adipogenesis.- 8.3.Inflammation in adipose tissue.- 8.4.
Energy homeostasis and hormonal regulation of food uptake.- 8.5.Genetics of obesity.- 9.Insulin resistance and diabetes.- 9.1.
Glucose homeostasis.- 9.2.Insulin resistance in skeletal muscle and liver.- 9.3.β cell failure.- 9.
4.Definition of diabetes.- 9.5.Disturbed glucose homeostasis in T2D and its treatment.- 9.6.Genetics and epigenetics of T2D.
- 10.Heart disease and the metabolic syndrome.- 10.1.Hypertension.- 10.2.Mechanisms of atherosclerosis .
- 10.3.Lipoproteins and dyslipidemias.- 10.4.Whole body's perspective of the metabolic syndrome.- 10.5.
Metabolic syndrome in key metabolic organs.- 10.6.Genetics and epigenetics of the metabolic syndrome.