Jules Berman received his bachelor's degrees in Mathematics and Earth and Planetary Sciences from Massachusetts Institute of Technology, his Ph.D. from Temple University, and his M.D. from the University of Miami. He received post-doctoral training in the Laboratory of Experimental Pathology in the National Cancer Institute, at NIH. He received residency training at the George Washington University Medical Center and is board certified in anatomic pathology and in cytopathology. He served as the chief of anatomic pathology at the VA Hospital in Baltimore where he held adjunct appointments at Johns Hopkins Medical Center and the University of Maryland Medical Center.

From 1998 to 2005 he was program director for Pathology Informatics in the Cancer Diagnosis Program at the National Cancer Institute. Jules Berman has first-authored more than 100 publications. He is now a free-lance author and the past President of the Association for Pathology Informatics.