Why are humans, who are motivated by self-preservation, also motivated to engage in behaviors that threaten and even extinguish their existence? The present work has given thought to this question and examined the phenomenon of self-destruction through the perspectives of empirical psychology, psychoanalysis, analytical psychology, as well as existential-phenomenological psychology. The themes included in this book are: the emerging understanding of self-destructiveness in culture, religion, philosophy, and psychology; Bion's investigation into the self-destructive capacity of the mind; Heidegger's ontology of Being and the Enframing of technology; and identifying and delineating the 'who' who most experiences the impact of human-to-human destructiveness in our contemporary culture.