Contributorsxi Prefacexxv Abbreviationsxxvii Volume One SECTION 1 Cardiovascular Disease: Past, Present, and Future 1.A History of the Cardiac Diseases, and the Development of Cardiovascular Medicine as a Specialty3 Robert A. Harrington, Mark E. Silverman, and Charles F. Wooley 2.The Global Burden of Cardiovascular Diseases19 Catherine P. Benziger, Andrew E. Moran, and Gregory A.
Roth 3.Assessing and Improving the Quality of Care in Cardiovascular Medicine52 Yashashwi Pokharel and John A. Spertus SECTION 2 Foundations of Cardiovascular Medicine 4.Functional Anatomy of the Heart67 Joseph F. Malouf, Joseph J. Maleszewski, A. Jamil Tajik, and James B. Seward 5.
Normal Physiology of the Cardiovascular System101 Rodrigo Fernandez-Jimenez, Brian D. Hoit, Richard A. Walsh, Valentin Fuster, and Borja Ibanez 6.Molecular and Cellular Biology of the Heart125 Roger J. Hajjar, Kiyotake Ishikawa, and Thomas Thum 7.Biology of the Vessel Wall144 Hillary Johnston-Cox, Valentin Fuster, and Jason C. Kovacic 8.Molecular and Cellular Development of the Heart161 Miguel Torres and Silvia Martín-Puig 9.
Genetic Basis of Cardiovascular Disease174 Eloisa Arbustini, Valentina Favalli, Nupoor Narula, Eliana Disabella, and Maurizia Grasso v 10.Stem Cells and the Cardiovascular System205 Karim Sallam and Joseph C. Wu SECTION 3 Evaluation of the Patient 11.The History, Physical Examination, and Cardiac Auscultation225 William R. Miranda and Rick A. Nishimura 12.Surface Electrocardiography252 Antoni Bayés de Luna, Diego Goldwasser, Miquel Fiol, and Antoni Bayés-Genis 13.Electrocardiographic Exercise Testing318 Gregory S.
Thomas and Myrvin H. Ellestad 14.Cardiac Radiography335 Geoffrey D. Rubin 15.Echocardiography353 Thomas H. Marwick, Anthony N. DeMaria, Daniel G. Blanchard, and William A.
Zoghbi 16.Magnetic Resonance Imaging of the Heart433 W. Gregory Hundley, Christopher M. Kramer, and Javier Sanz 17.Computed Tomography of the Heart469 Amir Ahmadi, Jagat Narula, and Jonathon Leipsic 18.Nuclear Cardiology499 Daniel S. Berman, Rory Hachamovitch, Leslee J. Shaw, Sean W.
Hayes, Piotr J. Slomka, Guido Germano, and Jagat Narula 19.Positron Emission Tomography in Heart Disease553 K. Lance Gould, Heinrich Schelbert, and Jagat Narula 20.Cardiac Catheterization, Cardiac Angiography, and Coronary Blood Flow and Pressure Measurements606 Morton J. Kern and Arnold H. Seto 21.Coronary Intravascular Imaging657 Christos V.
Bourantas, Yoshinobu Onuma, Renu Virmani, Jagat Narula, and Patrick W. Serruys 22.Magnetic Resonance Imaging and Computed Tomography of the Vascular System686 Marc R. Dweck, Michelle C. Williams, Prakash Krishnan, Valentin Fuster, Jagat Narula, and Zahi A. Fayad viContents SECTION 4 Systemic Arterial Hypertension 23.Epidemiology of Hypertension703 Nathan D. Wong and Stanley S.
Franklin 24.Pathophysiology of Hypertension720 John E. Hall, Joey P. Granger, Daniel W. Jones, and Michael E. Hall 25.Diagnosis and Treatment of Hypertension751 Lawrence R. Krakoff SECTION 5 Metabolic Disorders and Cardiovascular Disease 26.
The Metabolic Syndrome767 Michael A. Via and Jeffrey I. Mechanick 27.Obesity and Cardiovascular Disease776 W. Timothy Garvey and Jeffrey I. Mechanick 28.Diabetes and Cardiovascular Disease789 Michael E. Farkouh, Elliot J.
Rayfield, and Valentin Fuster 29.Hyperlipidemia817 Robert S. Rosenson and Scott M. Grundy SECTION 6 Cigarette Smoking and Cardiovascular Diseases 30.Epidemiology of Smoking and Pathophysiology of Cardiovascular Damage849 Sunil K. Agarwal, Petra Maslov, Jagat Narula, and Valentin Fuster 31.Preventing and Mitigating Smoking-Related Heart Disease860 Sara Kalkhoran and Stanton Glantz SECTION 7 Atherosclerosis and Coronary Heart Disease 32.Atherothrombosis: Disease Burden, Activity, and Vulnerability871 Erling Falk and Valentin Fuster 33.
Coronary Thrombosis: Local and Systemic Factors880 Juan Jose Badimon, Borja Ibanez, Valentin Fuster, and Lina Badimon 34.Coronary Blood Flow and Myocardial Ischemia893 K. Lance Gould, Henry Gewirtz, and Jagat Narula 35.Nonobstructive Atherosclerotic and Nonatherosclerotic Coronary Heart Disease923 David E. Winchester and Carl J. Pepine 36.Definitions of Acute Coronary Syndromes946 Usman Baber, David Holmes, Jonathan Halperin, and Valentin Fuster 37.Pathology of Myocardial Infarction and Sudden Death954 Maria E.
Romero, Rodrigo Fernandez-Jimenez, Elena Ladich, Valentin Fuster, Borja Ibanez, and Renu Virmani 38.Molecular and Cellular Mechanisms of Myocardial Ischemia/Reperfusion Injury977 Borja Ibanez, Gerd Heusch, David García-Dorado, Valentin Fuster, and Derek Yellon 39.Evaluation and Management of Non-ST-Segment Elevation Myocardial Infarction995 David J. Moliterno and James L. Januzzi, Jr. 40.ST-Segment Elevation Myocardial Infarction . 1017 Manesh R.
Patel, Mandeep Singh, Bernard J. Gersh, and William O''Neill 41.Antiplatelet and Anticoagulant Therapy in Acute Coronary Syndromes1055 Dominick J. Angiolillo, Gregory R. Giugliano, Daniel I. Simon, and Roxana Mehran 42.Percutaneous Coronary Interventions in Acute Myocardial Infarction and Acute Coronary Syndromes1109 William O''Neill, Cindy Grines, and George Dangas 43.The Evaluation and Management of Stable Ischemic Heart Disease1132 Bradley A.
Maron, Bernard J. Gersh, and Patrick T. O''Gara 44.Coronary Artery Bypass Grafting and Percutaneous Interventions in Stable Ischemic Heart Disease1160 Michael E. Farkouh, Samin K. Sharma, Matthew I. Tomey, John Puskas, and Valentin Fuster 45.Rehabilitation of the Patient with Coronary Heart Disease1173 Mary Ann McLaughlin Contentsvii SECTION 8 Valvular Heart Disease 46.
Acute Rheumatic Fever1187 Liesl Zühlke, Jagat Narula, and Jonathan R. Carapetis 47.Aortic Valve Disease1196 Blase A. Carabello and Rebecca T. Hahn 48.Degenerative Mitral Valve Disease1215 Javier G. Castillo, David H. Adams, Blasé A.
Carabello, and Partho P. Sengupta 49.Ischemic Mitral Regurgitation1238 John D. Groarke, Blasé A. Carabello, and Patrick T. O''Gara 50.Mitral Stenosis1248 Vinay K. Bahl, Ravi S.
Math, and Blasé A. Carabello 51.Tricuspid and Pulmonary Valve Disease1260 Joanna Y. Chikwe and Javier G. Castillo 52.Prosthetic Heart Valves1277 Joanna Chikwe and Javier G. Castillo 53.Antithrombotic Therapy for Valvular Heart Disease1300 Vinay K.
Bahl and Ravi S. Math 54.Management of Mixed Valvular Heart Disease1310 Blasé A. Carabello Volume Two SECTION 9 Congenital Heart Disease 55.Mendelian Basis of Congenital and Other Cardiovascular Diseases1319 Ali J. Marian, Ramon Brugada, and Robert Roberts 56.Congenital Heart Disease in Adolescents and Adults1363 Jeannette P. Lin, Jamil A.
Aboulhosn, and John S. Child SECTION 10 Myocardial, Pericardial, and Endocardial Diseases 57.Classification of Cardiomyopathies1397 Jagat Narula, Barry J. Maron, Navneet Narula, and Eloisa Arbustini 58.Dilated Cardiomyopathy1408 Eloisa Arbustini, Alessandra Serio, Valentina Favalli, G.William Dec, and Jagat Narula 59.Hypertrophic Cardiomyopathies1443 Luís R. Lopes and Perry M.
Elliott 60.Left Ventricular Noncompaction1465 Eloisa Arbustini, Alessandra Serio, Valentina Favalli, Nupoor Narula, and Maurizia Grasso 61.Restrictive Heart Diseases1482 Eloisa Arbustini, Alessandra Serio, Valentina Favalli, G.William Dec, Giovanni Palladini, and Jagat Narula 62.Arrhythmogenic Cardiomyopathy1509 Srinivas R. Dukkipati, Peter J. Mohler, Lorenzo Paolo Giuliani, Valentina Favalli, Jagat Narula, and Eloisa Arbustini 63.Myocarditis1528 Eloisa Arbustini, Manuela Agozzino, Valentina Favalli, and Jagat Narula 64.
The Athlete and the Cardiovascular System1561 N. A. Mark Estes III, Mark S. Link, and Barry J. Maron 65.Cardiovascular Disease in the Elderly: Pathophysiology and Clinical Implications1571 Joshua M. Stolker, Dae H. Kim, and Michael W.
Rich 66.Pericardial Diseases1594 William R. Miranda, Massimo Imazio, Kevin L. Greason, John M. Stulak, and Jae K. Oh 67. Infective Endocarditis . 1621 Joseph S.
Alpert and Stephen A. Klotz SECTION 11 Heart Failure 68.Pathophysiology of Heart Failure. 1651 Hanna K. Gaggin and G. William Dec 69.The Epidemiology of Heart Failure . 1674 Deepak K.
Gupta, Charlotte Andersson, Ramachandran S. Vasan, and Thomas J. Wang 70.The Diagnosis and Management of Chronic Heart Failure . 1690 Tariq Ahmad, Javed Butler, and Barry Borlaug 71.Evaluation and Management of Acute Heart Failure .